For longtime viewers of General Hospital, 2025 has been nothing short of emotional upheaval. Beloved characters are vanishing from the screen, storylines are taking devastating turns, and backstage decisions have spilled into headlines. These exits are not just casting changes—they are deeply personal for a fanbase that has grown up with these faces for decades. From shocking deaths to emotional goodbyes and controversial departures, here is a breakdown of the most high-profile actors who left the canvas, how their stories ended, and how fans reacted when the curtain fell.
After 21 years as one of Port Charles’s defining faces, Kelly Monaco’s exit shook fans to the core. Sam McCall died unexpectedly following a heroic liver donation to Lulu Spencer. The abruptness felt like a betrayal to many, especially as Sam had just deepened her relationship with Dante.
Fans erupted in grief and anger. One wrote “GH made one of the worst decisions ever, killing off this legacy character!” Another praised Kelly’s dedication: “Thank you, Kelly Monaco, for giving us Sam McCall — who will be greatly missed.
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